Expression and significance of MMP-7, c-Jun and c-Fos in rats skin photoaging
Asian Pacific Journal of Tropical Medicine
;
(12): 768-770, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-819968
ABSTRACT
OBJECTIVE@#To investigate the expression and significance of the MMP-7, c-Jun and c-Fos in rat photoaging skin.@*METHODS@#A total of 45 SD rats were randomly divided into control group, model group, natural recovery group, physiological saline injection group and dermal pluripotent stem cells transplantation (DMSCs group), model group, natural recovery group, physiological saline injection group. DMSCs were treated with UV lamp irradiation to establish light aging skin model. Rats were then sacrificed after model prepared, no treatment was processed in the natural recovery group. Saline injections was adopted in saline group, DESCs group was treated with DESCs transplantation. Rats were sacrificed after 4 weeks. The expression of MMP-7, c-Jun and c-Fos were detected using the immunohistochemical method.@*RESULTS@#In model group, MMP 7 positive expression was higher than that in the other 4 groups, but without statistically difference (P>0.05); c-Jun, c-Fos expression were higher than that in the control group and DESCs group (P0.05).@*CONCLUSIONS@#MMP-7, c-Jun and c-Fos can be used as diagnosis indicators in the early stage of light aging, and they jointly participate in its development. DMSCs transplants is effective in treating light aging skin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Efeitos da Radiação
/
Pele
/
Raios Ultravioleta
/
Envelhecimento
/
Expressão Gênica
/
Proteínas Proto-Oncogênicas c-jun
/
Proteínas Proto-Oncogênicas c-fos
/
Metaloproteinase 7 da Matriz
/
Genética
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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