SIRT3 expression in hepatocellular carcinoma and its impact on proliferation and invasion of hepatoma cells
Asian Pacific Journal of Tropical Medicine
;
(12): 649-652, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-819988
ABSTRACT
OBJECTIVE@#To observe expression of SIRT3 in normal liver tissue, cirrhotic tissue and hepatocellular carcinoma (HCC) tissues, and to explore the significance of SIRT3 in primary HCC.@*METHODS@#SIRT3 expression was detected in 10 normal cases, 30 cases with, 30 HCC cases by immunohistochemical and Western-blotting method.@*RESULTS@#Immunohistochemical assay showed that the SIRT3 positive expression rates were 100.0% (10/10), 96.7% (29/30) and 60.0% (18/30), respectively in normal group, paracancer group and HCC group. And the SIRT3 expression in HCC group was significantly lower than in normal group and paracancer group (P<0.05). Western-blotting showed the SIRT3 expression in cancer tissue was 0.29±0.07, significantly lower than that in paracancer group and normal group (P<0.05). SIRT3 expression was related to the differentiation degree and portal vein tumor thrombus (P<0.05).@*CONCLUSIONS@#Abnormal expression of SIRT3 is closely related to the biological behavior of primary HCC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Fisiologia
/
Imuno-Histoquímica
/
Carcinoma Hepatocelular
/
Hepatócitos
/
Proliferação de Células
/
Sirtuína 3
/
Fígado
/
Cirrose Hepática
/
Neoplasias Hepáticas
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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