Therapeutic efficacy of artemisinin combination therapies and prevalence of S769N mutation in PfATPase6 gene of Plasmodium falciparum in Kolkata, India
Asian Pacific Journal of Tropical Medicine
;
(12): 443-448, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-820024
ABSTRACT
OBJECTIVE@#To study the in vivo efficacy of these two ACTs in the treatment of Plasmodium falciparum (P. falciparum malaria) in Kolkata and to determine the prevalence of mutant S769N codon of the PfATPase6 gene among field isolates of P. falciparum collected from the study area.@*METHODS@#A total of 207P. falciparum positive cases were enrolled randomly in two study arms and followed up for 42 days as per WHO (2009) protocol. A portion of PfATPase6 gene spanning codon S769N was amplified and sequenced by direct sequencing method.@*RESULTS@#It was observed that the efficacy of both the ACT regimens were highly effective in the study area and no mutant S769N was detected from any isolate.@*CONCLUSIONS@#The used, combination AS+SP is effective and the other combination AM+LF might be an alternative, if needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parasitologia
/
Plasmodium falciparum
/
Resistência a Medicamentos
/
Dados de Sequência Molecular
/
Sequência de Bases
/
Resultado do Tratamento
/
Malária Falciparum
/
Genes de Protozoários
/
ATPases Transportadoras de Cálcio
/
Artemisininas
Tipo de estudo:
Guia de Prática Clínica
/
Estudo de prevalência
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
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