Anti-inflammatory effects of fatty acids isolated from Chromolaena odorata
Asian Pacific Journal of Tropical Medicine
;
(12): 760-763, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-820060
ABSTRACT
OBJECTIVE@#To identify inhibitors of nitric oxide production and NF-κB activity from Chromolaena odorata (C. odorata).@*METHODS@#The compounds isolated from the aerial parts of C. odorata by bioassay-guided fractionation were investigated for their inhibitory effects on the NO production and NF-κB activity in LPS-stimulated RAW264.7 cells.@*RESULTS@#Six fatty acids (S)-coriolic acid (1), (S)-coriolic acid methyl ester (2), (S)-15,16-didehydrocoriolic acid (3), (S)-15,16-didehydrocoriolic acid methyl ester (4), linoleamide (5) and linolenamide (6) were isolated. All compounds inhibited the NO production at concentrations consistent with those required for NF-κB inhibition. Compound 2 was the most active with the IC(50) values of 5.22 and 5.73 μM. The addition of a double bond in the fatty chain decreased the inhibitory effects while the methyl esterification increased the activities.@*CONCLUSIONS@#The fatty acid components in C. odorata with NF-κB inhibitory activity could explain the anti-inflammation property of this plant in traditional medicine. This study could also contribute to the better use of C. odorata for human health care.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Extratos Vegetais
/
Linhagem Celular
/
Química
/
NF-kappa B
/
Chromolaena
/
Componentes Aéreos da Planta
/
Ácidos Graxos
/
Macrófagos
/
Óxido Nítrico
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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