Inhibitory effect of two Indian medicinal plants on aldose reductase of rat lens in vitro
Asian Pacific Journal of Tropical Medicine
;
(12): 694-697, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-820070
ABSTRACT
OBJECTIVE@#To assesse the inhibitory effect of alcoholic extract of two Indian medicinal plants namely Ceasalpinia digyna Rottler and, Alangium lamarckii Thwaits on aldose reductase (AR) of rat lens.@*METHODS@#Rats lens were enucleated through posterior approach and their homogenate was prepared and centrifuged to obtain a clear supernatant for the determination of AR activity and protein content.@*RESULTS@#The alcoholic extract of Ceasalpinia digyna and Alangium lamarckii had a potent inhibitory effect on the lens AR enzyme. The IC(50) values of alcoholic extract of the selected plants were calculated and were (46.29±11.17) and (106.00±5.11) μg/mL, respectively. Quercetin was used as a positive control and its IC(50) value was (2.95±1.53) μg/mL.@*CONCLUSIONS@#Thus, it is concluded that alcoholic extracts of the selected plant exhibit significant inhibitory effects on AR in the rat lens in vitro.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Catarata
/
Extratos Vegetais
/
Química
/
Aldeído Redutase
/
Alangiaceae
/
Tratamento Farmacológico
/
Inibidores Enzimáticos
/
Fabaceae
/
Cristalino
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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