Colonic expression of Runx3 protein and TGF-β(1) and their correlation in patients with irritable bowel syndrome
Asian Pacific Journal of Tropical Medicine
;
(12): 547-549, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-820098
ABSTRACT
OBJECTIVE@#To investigate the role of Runx3 protein and TGF-β(1) in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins.@*METHODS@#Colonic tissue was collected from patients with IBS and normal persons. The colonic expression of Runx3 protein and TGF-β(1) was detected with immunohistochemistry method. Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.@*RESULTS@#Compared with their counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β(1) (P>0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β(1) in patients with IBS(P<0.05).@*CONCLUSIONS@#The role of Runx3 protein and TGF-β(1) in the pathogenesis of IBS remains to be further studied.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Imuno-Histoquímica
/
Regulação da Expressão Gênica
/
Colo
/
Síndrome do Intestino Irritável
/
Subunidade alfa 3 de Fator de Ligação ao Core
/
Fator de Crescimento Transformador beta1
/
Genética
/
Metabolismo
Limite:
Humanos
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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