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Expression of NF-κB and osteopontin of synovial fluid of patients with knee osteoarthritis
Article em En | WPRIM | ID: wpr-820513
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVE@#To explore the significance of osteopontin and nuclear factor κB (NF-κB) expression in patients with knee osteoarthritis.@*METHODS@#RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin (OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures, and analyze the relationship between the expressiones of them.@*RESULTS@#OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group. the result showed statistical significance (P<0.05). There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).@*CONCLUSIONS@#The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.
Assuntos
Texto completo: 1 Índice: WPRIM Assunto principal: Líquido Sinovial / RNA Mensageiro / Estudos de Casos e Controles / Western Blotting / Reação em Cadeia da Polimerase / NF-kappa B / Estatísticas não Paramétricas / Osteoartrite do Joelho / Osteopontina / Genética Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2013 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Líquido Sinovial / RNA Mensageiro / Estudos de Casos e Controles / Western Blotting / Reação em Cadeia da Polimerase / NF-kappa B / Estatísticas não Paramétricas / Osteoartrite do Joelho / Osteopontina / Genética Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2013 Tipo de documento: Article