Expression of NF-κB and osteopontin of synovial fluid of patients with knee osteoarthritis
Asian Pacific Journal of Tropical Medicine
; (12): 379-382, 2013.
Article
em En
| WPRIM
| ID: wpr-820513
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To explore the significance of osteopontin and nuclear factor κB (NF-κB) expression in patients with knee osteoarthritis.@*METHODS@#RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin (OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures, and analyze the relationship between the expressiones of them.@*RESULTS@#OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group. the result showed statistical significance (P<0.05). There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).@*CONCLUSIONS@#The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.
Texto completo:
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Índice:
WPRIM
Assunto principal:
Líquido Sinovial
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RNA Mensageiro
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Estudos de Casos e Controles
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Western Blotting
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Reação em Cadeia da Polimerase
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NF-kappa B
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Estatísticas não Paramétricas
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Osteoartrite do Joelho
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Osteopontina
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Genética
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2013
Tipo de documento:
Article