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Phytochemical composition and in vitro antioxidant activity of aqueous extract of Aerva lanata (L.) Juss. ex Schult. Stem (Amaranthaceae)
Asian Pacific Journal of Tropical Medicine ; (12): 180-187, 2013.
Artigo em Inglês | WPRIM | ID: wpr-820545
ABSTRACT
OBJECTIVE@#To analyze the phytochemical composition and in vitro antioxidant properties of aqueous extract of Aerva lanata (A. lanata) stem.@*METHODS@#During the preliminary phytochemical analysis, the aqueous extract of A. lanata was screened for the presence of carbohydrates, proteins, phenolic compounds, oil and fats, saponins, flavonoids, alkaloids, tannins and phytosterols. Antioxidant activity of the extract was determined by 2, 2-diphenyl-1-picrylhydrazyl radical scavenging activity, metal chelating activity, reducing power activity and DNA damage inhibition activity. Analysis of phenolic compounds was performed by Folin-Ciocalteau reagent method and gradient high performance liquid chromatography technique.@*RESULTS@#Preliminary phytochemical analysis exhibited the presence of phenolic compounds, saponins, flavonoids, tannins and phytosterols as major phytochemical groups. The extract exhibited high 2, 2-diphenyl-1-picrylhydrazyl radical scavenging activity (IC(50)= 110.74 μg/mL), metal chelating activity (IC(50)= 758.17 μg/mL), reducing power activity and DNA damage inhibition efficiency. The extract was reported to possess a high amount of total phenolic content and some of them were identified as gallic acid (3,4,5-OH), apigenin-7-O-glucoside (apigetrin), quercetin-3-O-rutinoside (rutin) and myricetin (3,5,7,3,4,5-OH) by high performance liquid chromatography analysis. The extract was found non toxic towards human erythrocytes in the hemolytic assay (IC(50) = 24.89 mg/mL).@*CONCLUSIONS@#These results conclud that A. lanata stem possesses high antioxidant activity and can be used for the development of natural and safe antioxidant compounds.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Fenóis / Fitosteróis / Picratos / Saponinas / Taninos / Flavonoides / Compostos de Bifenilo / Dano ao DNA / Extratos Vegetais Limite: Humanos Idioma: Inglês Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Fenóis / Fitosteróis / Picratos / Saponinas / Taninos / Flavonoides / Compostos de Bifenilo / Dano ao DNA / Extratos Vegetais Limite: Humanos Idioma: Inglês Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2013 Tipo de documento: Artigo