Your browser doesn't support javascript.
loading
Determinants of quinolone resistance in Escherichia coli causing community-acquired urinary tract infection in Bejaia, Algeria
Asian Pacific Journal of Tropical Medicine ; (12): 462-467, 2014.
Artigo em Inglês | WPRIM | ID: wpr-820670
ABSTRACT
OBJECTIVE@#To investigate the mechanisms of quinolone resistance and the association with other resistance markers among Esherichia coli (E. coli) strains isolated from outpatient with urinary tract infection in north of Algeria.@*METHODS@#A total of 30 nalidixic acid-resistant E. coli isolates from outpatient with urinary tract infections from January 2010 to April 2011 in north of Algeria (Bejaia) were studied. Antimicrobial susceptibility was determined by disc diffusion assay, minimal inhibitory concentrations (MIC) of quinolone were determined by microdilution. Mutations in the Quinolone Resistance-Determining Region (QRDR) of gyrA and parC genes and screening for qnr (A, B and S) and bla genes were done by PCR and DNA sequencing.@*RESULTS@#Most of the E. coli isolates (56.66%) were shown to carry mutations in gyrA and parC (gyrA Ser83Leu + Asp87Asn and parCSer80Ile). While, 16.66% had only an alteration in gyrA Ser83Leu. One isolate produced qnrB-like and two qnrS-like. Four isolates were CTX-M-15 producers associated with TEM-1 producing in one case. Co-expression of blaCTX-M-15 and qnrB was determined in one E. coli isolate.@*CONCLUSIONS@#Our findings suggested the community emergence of gyrA and parC alterations and Qnr determinants that contributed to the development and spread of fluoroquinolone resistance in Algerian E. coli isolates.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Infecções Urinárias / Testes de Sensibilidade Microbiana / Epidemiologia / Infecções Comunitárias Adquiridas / Quinolonas / Farmacorresistência Bacteriana / Argélia / Escherichia coli / Infecções por Escherichia coli Limite: Humanos País/Região como assunto: África Idioma: Inglês Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2014 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Farmacologia / Infecções Urinárias / Testes de Sensibilidade Microbiana / Epidemiologia / Infecções Comunitárias Adquiridas / Quinolonas / Farmacorresistência Bacteriana / Argélia / Escherichia coli / Infecções por Escherichia coli Limite: Humanos País/Região como assunto: África Idioma: Inglês Revista: Asian Pacific Journal of Tropical Medicine Ano de publicação: 2014 Tipo de documento: Artigo