The therapeutic effect of fluorouracil combined with radiotherapy on patients with primary liver cancer and its effect on serum LPO and MDA levels / 公共卫生与预防医学

ABSTRACT

Objective To explore the therapeutic effect of fluorouracil combined with radiotherapy on patients with primary liver cancer and its effect on the levels of serum lipid peroxide (LPO) and malondialdehyde (MDA). Methods From March 2016 to March 2017, a total of 108 patients with primary liver cancer were randomly divided into two groups radiotherapy group and combined treatment group, with 54 cases in each group. The patients in the radiotherapy group were treated with radiotherapy, while the patients in the combined treatment group were treated with fluorouracil combined with radiotherapy. Biochemical assays were used to detect the levels of aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), alanine aminotransferase (ALT), fibrinogen (FIB), activated partial thromboplastin time (APTT), and prothrombin time (PT). The enzyme-linked immunosorbent assay was used to detect serum hyaluronidase (HA), laminin (LN), and type III procollagen (PCIII) levels. The flow cytometry was used to detect T lymphocyte subgroup levels. LPO and MDA were detected by immunoturbidimetry. The total effective rate was compared between the two groups. Results The levels of AST, GGT and ALT in the combined treatment group were significantly lower than those in the radiotherapy group (P<0.05). After treatment, the FIB level in the combined treatment group was higher than that in the radiotherapy group, and the APTT and Pt levels were lower than those in the radiotherapy group (P<0.05). The levels of HA, LN and PCIII in the combined treatment group were lower than those in the radiotherapy group (P<0.05). After treatment, the CD8+ level in the combined treatment group was lower than that in the radiotherapy group, while the CD4+ and CD3+ levels were higher than those in the radiotherapy group (P<0.05). The level of LPO and MDA in the combined treatment group was lower than that in the radiotherapy group (P<0.05). The total effective rate of the combined treatment group was higher than that of the radiotherapy group (P<0.05). Conclusion The treatment of primary liver cancer patients with fluorouracil combined with radiotherapy could improve the liver function and coagulation function, improve the immune function, and reduce the severity of liver fibrosis and oxidative stress response of patients. The effect of the combination treatment was significant.