Relationship between interleukin-6 -572 gene polymorphism and aggressive periodontitis in Chinese / 口腔疾病防治

ABSTRACT

Objective@#To investigate the association between interleukin-6 -572 gene polymorphism and aggressive periodontitis. @*Methods @#A case-control study involved 83 patients with aggressive periodontitis (AgP) and 69 health controls was held, and the genotype and allele distributions of interleukin-6 -572 gene polymorphism were analyzed by PCR-RFLP. @* Results @#There was statistically significant differences in the genotype distribution by the chi-square test in the two groups (χ2 = 13.710, P=0.001). The distribution of allele frequencies in AgP group was statistically different (χ2=13.213, P < 0.001) from the healthy control group, and the OR for the G allele is 2.988 (95%CI 1.634-5.465) when compared with the C allele.@*Conclusion@#IL-6 -572 gene polymorphism is associated with the susceptibility to AgP in Chinese Han population of Guangdong, and the IL-6 -572 G allele might be a risk factor of the genetic susceptibility to AgP.