Relationship between ferroptosis and oxidative stress and its research progress in locomotor diseases / 医学研究生学报

ABSTRACT

Ferroptosis is an iron-dependent, non-apoptotic form of cell death characterized by accumulation of intracellular lipid reactive oxygen species. It exists in many fields such as nervous system, tumor, acute kidney injury, ischemia reperfusion injury. Oxidative stress (OS) is resulted from by excessive accumulation of ROS produced by an organism undergoing aerobic metabolism. Both of these eventually lead to excessive ROS accumulation, which leads to cell damage and death. This paper first summarized the relationship between ferroptosis and oxidative stress, and then described the current achievement of research on ferroptosis in locomotor diseases, trying to provide a theoretical support to find ferroptosis in more diseases through taking the oxidative stress as a bridge.