A study on genetic polymorphisms of rs600231 and rs4102217 loci in promoter of MALAT1 gene in Guangxi population / 临床检验杂志
Chinese Journal of Clinical Laboratory Science
; (12): 941-945, 2019.
Article
em Zh
| WPRIM
| ID: wpr-821925
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WPRO
ABSTRACT
Objective@#To investigate the single nucleotide polymorphisms (SNPs) of rs600231A/G and rs4102217 G/C in the promoter region of MALAT1 (metastasis associated in lung adenocarcinoma transcript 1) gene in the healthy population of Guangxi district and analyze the differences in the population among different regions. @*Methods@#The genotypes of rs600231A/G and rs4102217G/C of 207 healthy individuals in Guangxi were detected by SNPscan high-throughput technique. The genotype and allele frequency distributions were analyzed statistically with the data of HapMap-CEU (European population), HapMap-HCB (Beijing Han population), HapMap-JPT (Japanese population) and HapMap-YRI (African population) published by Human genome Haplotype Map (HapMap). @*Results@#There were three genotypes of AA (38.2%), AG (46.4%) and GG (15.4%) in rs600231A/G, and the differences were significantly different compared with the polymorphism of Japan and Africa population (HapMap-JPT and HapMap-YRI) (P<0.05). Compared with HapMap-CEU, the genotype difference was not statistically significant (P>0.05), but the allele distribution was statistically different (P<0.05). The rs4102217 G/C polymorphism contained GG(75.4%), CG(23.2%) and CC(1.4%), and the polymorphisms were significantly different from those in European and Japanese populations (P<0.05). There was no significant difference between gender in the polymorphisms of the two loci (P>0.05). @*Conclusion@#The polymorphisms of rs600231A/G and rs4102217G/C in the MALAT1 promoter region were found in Guangxi healthy population, and the distribution of polymorphisms may be different in the population of various regions. @*@#
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical Laboratory Science
Ano de publicação:
2019
Tipo de documento:
Article