Role of pyroptosis in the pathogenesis of hepatic fibrosis / 临床肝胆病杂志

ABSTRACT

Hepatic fibrosis is a reversible pathological reaction of the liver during the self-repair of various chronic liver injuries and can progress to liver cirrhosis and liver cancer. Pyroptosis is a new type of programmed cell death different from apoptosis and necrosis and is closely associated with the pathogenesis of hepatic fibrosis. This article reviews the latest research advances in the definition of pyroptosis, related activation pathways, and its role in hepatic stellate cells, hepatic parenchymal cells, Kupffer cells, and eosinophils, and it is pointed out that pyroptosis can induce liver inflammation, excessively activate hepatic stellate cells, and promote the development and progression of hepatic fibrosis, in order to provide new ideas and potential targets for clinical diagnosis and treatment.