Research progress on epigallocatechin-3-gallate in the prevention and treatment of oral cancer / 口腔疾病防治
Journal of Prevention and Treatment for Stomatological Diseases
;
(12): 468-471, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-822180
ABSTRACT
@#Epigallocatechin-3-gallate (EGCG) has antibacterial, anti-inflammatory, antitumor, and other functions. EGCG and its anticancer mechanism are hot research topics in the prevention and treatment of oral cancer. In this paper, the prevention and treatment effects of EGCG on oral cancer and its anticancer mechanism are reviewed. The results show that EGCG can regulate multiple cell metabolic signaling pathways, such as the G protein coupled receptor signaling pathway, mitogen-activated protein kinase (MAPK), and the Wnt signaling pathway, and it can regulate DNA methylation and act on RNA of oral cancer cells directly or indirectly through the oral cancer cell signal transduction network to inhibit the development of oral precancerous lesions and oral cancer. EGCG combined with 5-fluorouracil can enhance the curative effect and reduce adverse effects and is expected to be a new drug for the prevention and treatment of oral cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Prevention and Treatment for Stomatological Diseases
Ano de publicação:
2020
Tipo de documento:
Artigo
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