Research advances in the pathogenesis of nonalcoholic fatty liver disease-related hepatocellular carcinoma / 临床肝胆病杂志

ABSTRACT

Nonalcoholic steatohepatitis (NASH)/nonalcoholic fatty liver disease (NAFLD) has gradually become one of the main causes of hepatocellular carcinoma (HCC) in Western developed countries. Different from the typical evolution process of hepatitis, liver cirrhosis, and liver cancer, nearly 40% NAFLD patients can progress into HCC without experiencing liver cirrhosis, suggesting other mechanisms may play a role in this process. This article elaborates on the latest research advances in the pathogenesis of NAFLD-related HCC.