In vitro bioactive potential and chemical analysis of the n-hexane extract of the medicinal mushroom, Cordyceps militaris
Malaysian Journal of Microbiology
;
: 40-48, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-823231
ABSTRACT
@#Aims:
Cordyceps militaris is a medicinal mushroom from Ascomycota. The aims of this study were to explore and identify the chemical compounds extracted in the non-polar fraction of the mushroom and to examine the biological potential of this extract. Methodology andresults:
The n-hexane extract metabolites were identified using gas chromatography-mass spectrometry (GC-MS) and results revealed the presence of 37 compounds delivered from different chemical classes and were mainly comprised of fatty acids and their esters (72%), carboxylic acids and their esters (10.39%), and a sulphur compound (7.1%). The n-hexane extract recorded a promising antioxidant effect (80.9±1.5%) at 80 mg/mL total extract; potent cholesterol reduction activity (100%) was obtained after 96 h incubation by the total metabolites (4%). The cytotoxicity of the compounds revealed 50% cytotoxicity concentration (CC50) ˃ 1 mg/mL and anti-rotavirus SA-11 effect where inhibition of virus attachment and penetration into infected cells was recorded at 50% effective concentration (IC50) of 300±0.2 µg/mL. Conclusion, significance and impact of study This study confirmed the impact of the fatty acids produced by C. militaris as bioactive metabolites.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Malaysian Journal of Microbiology
Ano de publicação:
2020
Tipo de documento:
Artigo
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