The research progress on the relationship between 8-iso-prostaglandin F2α, oxidative stress and Henoch-Schonlein purpura / 国际儿科学杂志

ABSTRACT

8-iso-prostaglandin F2α is a stable end product of lipid peroxidation of cell membrane lipid arachidonic acid under oxidative stress,which is formed by non-enzymatic beta lysis and recombination.It is an ideal index for evaluating the degree of lipid peroxidation and damage.Oxidative stress can damage biological molecules,cause cell death and tissue damage,and participate in the process of Henoch-Schonlein purpura and kidney damage.This article reviews the oxidative stress state and lipid peroxidation process of the body,the production and significance of 8-iso-prostaglandin F2α,the mechanism of oxidative stress in the pathogenesis of Henoch-Schonlein purpura and renal damage,and the important clinical significance of measuring 8-iso-prostaglandin F2α for Henoch-Schonlein purpura,which will provide evidence for future targeted therapy.