Signaling pathway of early brain injury after subarachnoid hemorrhage / 国际脑血管病杂志

ABSTRACT

Early brain injury (EBI) refers to the direct damage and secondary pathophysiological changes of brain tissue within 72 h after aneurysmal subarachnoid hemorrhage.Studies have shown that a variety of signaling pathways are involved in the mechanism of EBI,such as ecoxy chloropropane Kelch sample related protein-1 (Keapl)-nuclear factor E2 related factor 2 (Nrf2)-antioxidant response element (ARE) pathway,Toll-like receptor 4 (TLR4)/nuclear factor-κB pathway,phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt) pathway.This article reviews the mechanisms of action of different signaling pathways involved in EBI.