Regulation of mTOR singnaling pathway by microRNA in hepatocellular carcinoma / 国际肿瘤学杂志

ABSTRACT

MicroRNA (miRNA)is a non-coding small molecule RNA,which is involved in the occu-rrence and development of tumor as an oncogene or tumor suppressor gene. The abnormal expression of many kinds of miRNAs in hepatocellular carcinoma (HCC)can directly or indirectly act on PI3K,Akt,mTOR, IGF-1R,TGF-β and other signal molecules in mTOR signal pathway,they are crucial in the appreciation,inva-sion and metastasis of HCC cells.