Effects of 5-hydroxytryptamine and receptors in tumorigenesis / 国际肿瘤学杂志

ABSTRACT

The role of 5-hydroxytryptamine (5-HT)has attracted more and more attention in the development of tumor. In addition to the synthesis of 5-HT by enterochromaffin cells,some tumor cells and im-mune cells can also secrete 5-HT,and there are different 5-HT receptors on the surface of these cells. 5-HT plays multiple biological effects through activating different receptors. 5-HT promotes the proliferation and inva-sion of tumor and induces the angiogenesis of tumor tissues through activating its corresponding receptors,such as 5-HT1D,and so on. Furthermore,various 5-HT receptors are expressed on the surface of immune cells. On the one hand,physiological doses of 5-HT promote the proliferation and secretion of immune cells. On the other hand,pathologic 5-HT has an effect on inducing the differentiation of immune cells in the direction of immuno-suppression,thus participating in the occurrence and development of tumor.