Diagnosis and treatment of IgG4-related pancreatitis / 中华消化外科杂志

ABSTRACT

Immunoglobulin G (IgG) 4-related pancreatitis,also named as type I autoimmune pancreatitis,is recognized as a pancreatic manifestation of IgG4-related disease.It is very hard to differentiate it from pancreatic cancer due to similar clinical manifestations with pancreatic cancer.Diagnosis of IgG4related pancreatitis mainly relies on pathological examination and imaging examination.Corticosteroids are the main treatment for IgG4-related pancreatitis,and the risk of relapse is still high with steroid taper or following withdrawal of steroids.Based on researches on IgG4-related pancreatitis and our clinical experience,the authors have analyzed and summarized pathogenesis,clinical manifestations,clinical diagnosis,differentiation from pancreatic cancer,clinical treatment of IgG4-related pancreatitis,and suggested that elucidation of its mechanism and induction of immunotherapy may improve its efficacy.