Influence of statins on incidence rate of short‐and long‐term cardio‐and cerebrovascular events in pa‐tients with hypertensive nephropathy／ / 心血管康复医学杂志

ABSTRACT

To observe influence of atorvastatin on incidence rate of short‐and long‐term cardio‐and cere‐brovascular events in patients with hypertensive nephropathy (HNP).Methods:A total of 130 HNP patients treated in our hospital were enrolled ,randomly and equally divided into routine treatment group and atorvastatin group (re‐ceived atorvastatin based on routine treatment ).After three‐month treatment ,renal function ,inflammatory fac‐tors ,vascular endothelial function ,hemorheology ,levels of blood lipids and blood pressure etc .before and after treatment were observed in two groups ;after one‐year follow‐up ,incidence rates of short‐(six months) and long‐term (one year) cardio‐and cerebrovascular events were recorded in two groups .Results: Compared with routine treatment group after three‐month treatment ,there were significant reductions in levels of urinary albumin [ (35. 85 ± 4. 98) mg／ml vs.(29.63 ± 4.51) mg／ml] ,serum creatinine [ (92. 11 ± 10.52) μmol／L vs.(86. 43 ± 10. 16) μmol／L] , blood urea nitrogen [ (8. 16 ± 0. 45) mmol／L vs.(7.19 ± 0. 36) mmol／L] ,serum procalcitonin [ (1. 21 ± 0. 67) ng／ml vs .(0.67 ± 0. 31) ng／ml] ,C reactive protein [(49. 51 ± 8.79) mg／L vs.(33. 37 ± 8.15) mg／L] ,blood pres‐sure [(152.78 ± 4.52)／(94.37 ± 3.69) mmHg vs.(141.89 ± 4.13)／(91.52 ± 3. 24) mmHg] ,blood lipids (except HDL‐C) ,high shear whole blood viscosity ,low shear whole blood viscosity ,hematocrit ,plasma viscosity and fi‐brinogen level in atorvastatin group , P＜0. 01 all.Compared with routine treatment group ,there were significant reductions in incidence rates of short‐ and long‐term unstable angina pectoris ,carotid artery stenosis and coronary stenosis ,and long‐term hemorrhagic stroke in atorvastatin group , P＜0.05 or ＜0.01. Conclusion:Statins can sig‐nificantly reduce incidence rates of short‐ and long‐term cardio‐ and cerebrovascular events in patients with hyper‐tensive nephropathy .