Influence of N‐acetylcysteine combined ulinastatin on pulmonary function in patients undergoing coro‐nary artery bypass grafting／ / 心血管康复医学杂志

ABSTRACT

To explore influence of N‐acetylcysteine (NAC ) combined ulinastatin on pulmonary function in patients undergoing coronary artery bypass grafting (CABG ).Methods: A total of 94 patients needed CABG from our hospital were randomly and equally divided into ulinastatin group and combined treatment group (received NAC based on ulinastatin group ).Postoperative mechanical ventilation time ,in‐hospital time ,pulmonary function indexes and prognosis were compared between two groups .Results:Compared with ulinastatin group ,there was sig‐nificant rise in surgery time [ (172.35 ± 10. 70) min vs .(177. 98 ± 10.56) min] ,and significant reductions in post‐operative mechanical ventilation time [ (23. 41 ± 6. 27) h vs.(15. 98 ± 6.34) h] and in‐hospital time [ (24. 11 ± 3.33) d vs.(21. 39 ± 3. 45) d] , P＜0.05 or ＜0.01 ;significant rise in partial pressure of oxygen in artery [ (85. 47 ± 9.16) mmHg vs .(98.26 ± 8. 96) mmHg] ,oxygenation index [ (504. 41 ± 44.76) mmHg vs .(541.53 ± 42.92) mmHg] ,and significant reductionsin alveolar‐arterial oxygen difference [ (51.69 ± 7.42) mmHg vs.(42. 13 ± 8. 64) mmHg] , respiratory index [ (0.60 ± 0.26) vs.(0. 43 ± 0. 12)] in combined treatment group after treatment , P＝0.001 all.After treatment ,serum levels of interleukin (IL )‐6 ,IL‐8 and CD11b／CD18 were significantly higher than those of before treatment in two groups ( P＝0.001 all) ,but levels of above inflammatory factors in combined treatment group were significantly lower than those of ulinastatin group , P＝0. 001 all ;there were no severe infec‐tions ,pneumothorax and death in two groups after surgery .Conclusion: N‐acetylcysteine combined ulinastatincan significantly inhibit inflammatory reactions ,improve pulmonary function and relieve pulmonary injury in patients undergoing coronary surgery .