Advance in biomarkers of neuromyelitis optica / 中华实验眼科杂志

ABSTRACT

Neuromyelitis optica (NMO) is an autoimmune,demyelinating disease of the central nervous system manifesting with optic neuritis and longitudinally extensive transverse myelitis.Aquaporin-4 (AQP4)-IgG is currently regarded as a specific biomarker of NMO.Nevertheless,AQP4-IgG seronegativity in 10％-25％ of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis.In this article,we reviewed current knowledge about biomarkers of NMO from AQP4,myelin-oligodendrocyte glycoprotein,AQP1 and glial fibrillary acidic protein,providing a new insight in the diagnosis of NMO.