Influence of selenium yeast combined with levothyroxine sodium on outcomes in type 2 diabetes mellitus patients complicated with chronic lymphocytic thyroiditis / 中国基层医药

ABSTRACT

Objective To investigate the clinical efficacy of combination therapy of selenium yeast and levothyroxine sodium in the treatment of type 2 diabetes mellitus complicated with chronic lymphocytic thyroiditis (CLT).Methods A total of 96 patients with type 2 diabetes mellitus complicated with CLT who admitted to Wenling Hospital of Traditional Chinese Medicine from June 2017 to December 2018 were randomly divided into control group and treatment group according to the digital table ,with 48 patients in each group.On the basis of stable blood sugar control,the control group received routine treatment with levothyroxine sodium tablets .The treatment group was given selenium yeast on the basis of the control group.The blood glucose, thyroid,clinical efficacy within 3 months of treatment were recorded.Results The total effective rate of the study group was 95.83%(46／48 ), which was significantly higher than 68.75%(33／48) of the control group (χ2 ＝12.080,P＜0.05).The levels of blood sugar and glycosylated hemoglobin in the study group were significantly lower than those in the control group after treatment (all P＜0.05),and the levels of C -peptide in the fasting and postprandial 2h were significantly higher than those in the control group(t＝4.927-8.725,all P＜0.05).After treatment,the serum selenium level in the study group was significantly higher than that in the control group ( P ＜0.05 ), and the serum TPOAb and TGAb levels were significantly lower than those in the control group ( t＝17.264-27.032,all P＜0.05).There were no statistically significant differences in serum TSH ,FT3 and FT4 levels between the two groups (t＝0.704-1.926,all P＞0.05). Conclusion The clinical efficacy of selenium yeast and levothyroxine in the treatment of type 2 diabetes with CLT is significantly better than traditional treatment.