Benefits and risks of intravenous thrombolysis in minor stroke and effects of combined urinary kallidinogenase on long-term prognosis of stroke / 中国医师杂志

ABSTRACT

Objective To explore the clinical benefits and risks of intravenous thrombolysis combined with urinary kallidinogenase in the treatment of minor stroke.Methods The clinical data of 86 patients with minor stroke were retrospectively analyzed.Patients who received intravenous thrombolysis combined with urinary kallidinogenase were included in observation group (n =48),and those who received intravenous thrombolysis alone were included in control group (n =38).Before treatment and after 2 weeks of treatment,the imaging blood flow perfusion parameters [cerebral blood flow (CBF),mean transit time (MTT),time to peak (TTP)],and breath holding test indexes [cerebral vascular reactivity (CVR),breath holding index (BHI)] and serum biochemical indicators [vascular endothelial growth factor (VEGF),basic fibroblast growth factor (bFGF)] were compared between the two groups.The occurrence of adverse drug reactions during course of treatment and rehabilitation effects at 3 months after treatment [US National Institutes of Health Stroke Scale (NIHSS),modified Rankin Scale (mRS)] were analyzed in the two groups.Results After 2 weeks of treatment,the CBF,CVR,BHI and serum levels of VEGF and bFGF in the two groups were significantly higher than those before treatment,and the indexes in observation group were significantly higher than those in control group (P ＜ 0.05).The MTT and TTP levels in the two groups were significantly higher than those before treatment,and the levels in observation group were significantly higher than those in control group (P ＜ 0.05).There was no significant difference in the incidence rate of adverse drug reactions between the two groups during course of treatment (P ＞ 0.05).At 3 months after treatment,there was no statistically significant difference in the effective rate of rehabilitation between the two groups (P ＞ 0.05),but the Mann-Whitney U rank sum test between-groups showed that the overall rehabilitation effects in observation group were significantly better than those in control group (P ＜ 0.05).Conclusions Intravenous thrombolysis has certain treatment effects in patients with minor stroke,and its safety is within the clinical controllable range.Combined with urinary kallidinogenase can obtain ideal longterm prognosis,and it is beneficial to the recovery of neurological function.