Effects of live attenuated polio vaccine on the immunogenicity of live attenuated rotavirus vaccine / 中华微生物学和免疫学杂志

ABSTRACT

Objective To evaluate whether simultaneous vaccination with live attenuated polio vaccine affects the immunogenicity of live attenuated rotavirus ( RV) vaccine. Methods Rotarix produced by GlaxoSmithKline was used as the research object. Two doses of Rotarix were orally administered on day 0 and month 1, and oral live attenuated polio vaccine (OPV) was administered on day 0, month 1 and month 2 according to the national vaccination plan. Healthy infants aged 6 to 16 weeks were randomly divided into two groupsinterval vaccination group ( Rotarix and OPV were vaccinated on different days) and simultane-ous vaccination group ( Rotarix and OPV were vaccinated on the same day) . Serum samples were collected on day 0, month 2 and month 12, and serum RV-IgA was measured by enzyme linked immunosorbent assay. Statistical analysis was performed to evaluate whether there were statistical differences in the seroconversion rate and level distribution of RV-IgA between the two groups. Results The seroconversion rate of serum RV-IgA in month 2 was 73. 84％ in the interval vaccination and 63. 95％ in the simultaneous vaccination group, and the difference between them was statistically significant (P<0. 05). The geometric mean concen-trations (GMC) of RV-IgA were 97 EU/ml and 90 EU/ml, respectively (P>0. 05). Compared with the simultaneous vaccination group, the seroconversion rate and GMC of serum RV-IgA in month 12 were higher in the interval vaccination group, and the differences were statistically significant (P<0. 05). Conclusions Simultaneous vaccination with live attenuated polio vaccine would affect the immune response of live attenua-ted rotavirus vaccine, especially the maintenance of RV-IgA antibody level.