Role of HIV-1 envelope protein gp120 in neuronal injury-induced cognitive impairment / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 32-37, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-824821
ABSTRACT
Objective To investigate the role of HIV-1 envelope protein gp120 in cognitive im-pairment induced by neuronal damage. Methods Western blot and immunofluorescence assay were used to detect microglia activation, inflammatory factor expression and neuronal damage after gp120 treatment. Neu-ronal damage and neurocognitive performance in gp120-transgenic mice were evaluated using immunohisto-chemical staining and behavioral analysis, respectively. Results In vivo and in vitro experiments showed that HIV-1 gp120 significantly induced the expression of caspase-1 and IL-1β, and indirectly caused neuro-nal synaptic shortening and neuronal damage (P<0. 05). Compared with wild-type mice, gp120-transgenic mice showed significant cortical and hippocampal glial activation, neuronal loss, dendritic damage and neu-rocognitive disorders. Conclusions HIV-1 gp120 might cause neuronal damage through activating the re-lease of inflammatory factor by microglia and involve in neurocognitive impairment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Microbiology and Immunology
Ano de publicação:
2020
Tipo de documento:
Artigo
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