Effects of aqueous extract of Notobasis syriaca on lipopolysaccharide-induced inflammation in rats
Asian Pacific Journal of Tropical Medicine
;
(12): 48-52, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-825813
ABSTRACT
Objective:
To investigate the effects of a dry aqueous extract of Notobasis syriaca (N. syriaca) on lipopolysaccharide (LPS)-induced inflammation in rats.Methods:
Rats were fed the dried extract [500 mg/(kgod)] for three consecutive days and then were intraperitoneally injected with LPS (1 mg/kg). Two hours after LPS injection, rats were sacrificed and blood and brain regions were collected. Inflammatory mediators’ levels in plasma and homogenates of brain regions were determined by ELISA.Results:
Pretreatment with the N. syriaca extract resulted in significant anti-inflammatory effects (P<0.05), including i) attenuated LPS-induced hypothermia; ii) decreased hypothalamus and hippocampus prostaglandin EConclusions:
These results suggest that N. syriaca possesses anti-inflammatory properties. Thus, it is possible that long-term consumption of this plant may result in beneficial pharmacological effects.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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