The Relationship Between Heart Rate Recovery and Brain Natruretic Peptide in Patients With Chest Discomfort
Korean Circulation Journal
;
: 172-178, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-8264
ABSTRACT
BACKGROUND AND OBJECTIVES:
The correlation between brain natruretic peptide (BNP) level and cardiac autonomic function has been studied in type 2 diabetic patients. However, there is limited data from patients with normal systolic function. We evaluated the association between heart rate recovery (HRR) representing autonomic dysfunction and three plasma BNP levels pre-exercise, post-exercise, and change during exercise in patients with normal systolic function. SUBJECTS ANDMETHODS:
Subjects included 105 patients with chest pain and normal systolic function. HRR was defined as the difference between the peak heart rate and the rate measured two minutes after completion of a treadmill exercise test. We measured plasma BNP levels before exercise, 5 minutes after completion of exercise, and during exercise (absolute value of difference between pre- and post-exercise BNP levels).RESULTS:
Patients with abnormal HRR values (< or =24 beats for the first 2 minutes of HRR) had lower high-density lipoprotein, lower peak heart rates, and higher pre- and post-exercise BNP levels than patients with normal HRR values. The patients with coronary artery disease (CAD) had abnormal HRR. However, no significant differences were found between the two groups in terms of history of hypertension (HTN), diabetes, and peak systolic blood pressure (SBP) and diastolic blood pressure (DBP). HRR was significantly associated with pre-exercise BNP (r=-0.36, p=0.004) and post-exercise BNP (r=-0.27, p=0.006), but not BNP changes. Further, pre-exercise BNP levels showed a greater association with HRR than post-exercise BNP levels.CONCLUSION:
HRR is independently associated with pre-exercise and post-exercise BNP levels, even in patients with normal systolic function.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Volume Sistólico
/
Tórax
/
Pressão Sanguínea
/
Dor no Peito
/
Doença da Artéria Coronariana
/
Encéfalo
/
Teste de Esforço
/
Coração
/
Frequência Cardíaca
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Circulation Journal
Ano de publicação:
2010
Tipo de documento:
Artigo
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