Genetic analysis of an infant with duplication of 22q12.1-q13.3 / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 555-558, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-826534
ABSTRACT
OBJECTIVE@#To explore the genetic basis for an infant with multiple malformations including congenital heart disease and cleft palate.@*METHODS@#The child and his parents were subjected to conventional chromosomal karyotyping and low-coverage massively parallel copy number variation sequencing (CNV-seq) analysis.@*RESULTS@#The infant was found to have a 46,X,add(Y)(q11.23) karyotype, and his CNV-seq result was seq [hg19] 22q12.1q13.3 (29 520 001-51 180 000)× 3. His parents were found to be normal by both methods.@*CONCLUSION@#The additional chromosomal material found on Yq, verified as duplication of 22q12.1-q13.3, may account for the abnormal phenotype in this infant. CNV-seq has provided a useful complement for the diagnosis and more accurate information for genetic counseling.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Anormalidades Múltiplas
/
Cromossomos Humanos Par 22
/
Testes Genéticos
/
Fissura Palatina
/
Variações do Número de Cópias de DNA
/
Duplicação Cromossômica
/
Genética
/
Cardiopatias Congênitas
/
Cariotipagem
Tipo de estudo:
Estudo prognóstico
Limite:
Criança
/
Humanos
/
Lactente
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2020
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS