Involvement of long non-coding RNAs in the pathogenesis of rheumatoid arthritis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 941-950, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-827678
ABSTRACT
Long non-coding RNA (lncRNA) plays a contributory role in rheumatoid arthritis (RA). In this review, we summarized the current findings of lncRNAs in RA, including cellular function and the potential mechanisms. Serum lncRNA levels are associated with serum proinflammatory cytokines and disease activity. LncRNAs regulate proliferation, migration, invasion and apoptosis of RA fibroblast-like synoviocytes (FLSs), modulate the differentiation of T lymphocytes and macrophages, and affect bone formation-destruction balance of chondrocytes. Besides, lncRNAs are involved in inflammation and cell motivation signaling pathways. In-depth research on lncRNAs may help elucidate the pathogenesis of RA and provides clues for novel treatment targets.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2020
Tipo de documento:
Artigo
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