Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 729-737, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-827782
ABSTRACT
A series of novel pyrano[2, 3-d]trizaole compounds were synthesized and their α-glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC74.0 ± 1.3 μmol·L) than acarbose. The molecular docking revealed that compound 10f could bind to α-glucosidase via the hydrophobic, π-π stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent α-glucosidase inhibitors.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2020
Tipo de documento:
Artigo
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