Recent advances of miRNAs in the development and clinical application of gastric cancer / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1856-1867, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-827908
ABSTRACT
Gastric cancer (GC) is one of the most common malignant tumors. The mechanism of how GC develops is vague, and therapies are inefficient. The function of microRNAs (miRNAs) in tumorigenesis has attracted the attention from many scientists. During the development of GC, miRNAs function in the regulation of different phenotypes, such as proliferation, apoptosis, invasion and metastasis, drug sensitivity and resistance, and stem-cell-like properties. MiRNAs were evaluated for use in diagnostic and prognostic predictions and exhibited considerable accuracy. Although many problems exist for the application of therapy, current studies showed the antitumor effects of miRNAs. This paper reviews recent advances in miRNA mechanisms in the development of GC and the potential use of miRNAs in the diagnosis and treatment of GC.
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2020
Tipo de documento:
Artigo
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