Memory T cells: strategies for optimizing tumor immunotherapy
Protein & Cell
; (12): 549-564, 2020.
Article
em En
| WPRIM
| ID: wpr-828771
Biblioteca responsável:
WPRO
ABSTRACT
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in (ex) vivo that, might be applicable in clinical practice.
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WPRIM
Idioma:
En
Revista:
Protein & Cell
Ano de publicação:
2020
Tipo de documento:
Article