Role of exosomes in the metastasis of pancreatic cancer / 临床肝胆病杂志

ABSTRACT

Although great achievements have been made in the diagnosis and treatment of pancreatic cancer in the past several decades, the 5-year survival rate of this disease is still below 10% due to high degree of malignancy, rapid progression, and strong invasion and metastasis. Exosomes are a class of nanoscale membranous vesicles that can be secreted by a variety of cells, and they carry various substances including proteins, lipids, and nucleic acids and participate in various physiological and pathological processes, such as intercellular material transport, information transmission, and development, progression, and metastasis of tumor. Studies have shown that exosomes play an important role in the metastasis of pancreatic cancer and can regulate the metastasis of pancreatic cancer by promoting epithelial-mesenchymal transition and angiogenesis to act on tumor microenvironment, affecting the formation of premetastatic microenvironment, and participating in the formation of immunosuppression microenvironment. This article reviews the research advances in exosomes in the metastasis of pancreatic cancer.