Role of matrix metalloproteinases-2 and matrix metalloproteinases-9 in the development and progression of chronic liver diseases / 临床肝胆病杂志

ABSTRACT

The degradation and remodelling of extracellular matrix are important pathophysiological phenomena during the progression of various chronic liver diseases. With the expanded research on matrix metalloproteinases (MMPs) in recent years, it has been found that MMPs can affect the degradation and remodelling of extracellular matrix, participate in the regulation of inflammation and immune responses through various mechanisms, and thus participate in the progression of liver diseases. This article reviews the basic characteristics of matrix metalloproteinase-2 and matrix metalloproteinase-9, their regulatory mechanisms, and their role in the development and progression of chronic liver diseases, so as to provide a basis for exploring new therapeutic strategies for chronic liver diseases.