Preliminary Report on the Correlation of Auditory Cognitive Evoked Potential and Clinical Improvement in Schizophrenics / 신경정신의학

ABSTRACT

OBJECTIVES: The purpose of this study was to see the correlation between the auditory cognitive evoked potential and the clinical improvement in schizophrenics. METHOD: The subjects were 23 patients with schizophrenia. Auditory cognitive evoked potential was examined at pretreatment or the acute phase of treatment. The change of symptom was assessed by the PANSS(Positive and Negative Syndrome Scale) before drug treatment and in the 4th week of treatment. RESULTS: The results were as follows 1) The change of positive subscale was positively correlated with P1 latency(p<.05), N1 latency (p<.05) and negatively correlated with P3 latency(p<.05), P2 amplitude(p<.05). 2) The change of negative subscale was negatively correlated with P3 latency(p<.05). 3) The change of general psychopathology subscale was negatively correlated with P3 latency(<.05). CONCLUSIONS:These results suggest that the auditory cognitive evoked potential in schizophrenic patients could be valuable on prediction of clinical improvement. But, further studies are required to support these results.