Myoclonus Induced by the Use of Gabapentin
Journal of Korean Neurosurgical Society
;
: 237-238, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-83444
ABSTRACT
Myoclonus is a rare side effect of gabapentin (GBP) and has been reported in patients with preexisting myoclonus, mental retardation, chronic static encephalopathy, diffuse brain damage, impaired renal function, or end stage renal disease. We report a case of myoclonus in a patient with normal renal function and no previous disorders. A 69-year-old female underwent diskectomy and foraminotomy at the left L4-L5 level. Postoperatively,she complained of paresthesia in her left leg, which was thought to be due to root manipulation during surgery. To relieve the paresthesia, she was given tramadol, an oral opioid agonist, and GBP. One week after GBP was increased to 900 mg per day, myoclonus developed, which severely impaired her normal activity. Her symptoms resolved 2 days after discontinuation of GBP. The coadministration of tramadol and GBP may mutually enhance the myoclonic potential of each drug. The causal relationship between GBP and myoclonus was suggested by cessation of myoclonus after GBP discontinuation despite continued therapy with tramadol.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parestesia
/
Tramadol
/
Encéfalo
/
Discotomia
/
Ácidos Cicloexanocarboxílicos
/
Foraminotomia
/
Ácido gama-Aminobutírico
/
Aminas
/
Analgésicos Opioides
/
Falência Renal Crônica
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Neurosurgical Society
Ano de publicação:
2008
Tipo de documento:
Artigo
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