Reye Syndrome: Light and Electron Microscopic Studies of 7 Cases
Yonsei Medical Journal
;
: 59-69, 1978.
Artigo
em Inglês
| WPRIM
| ID: wpr-8345
ABSTRACT
Histopathological and electron microscopical studies were made on 7 cases of Reye syndrome. Histologically brain edema with neuronal degeneration and fatty change in the liver were constant findings, and fatty change of kidneys, heart and pancreas were variably observed. Electron microscopy revealed characteristic mitochondrial abnormalities in the hepatocytes, proximal convoluted tubular cells of kidneys, pancreatic acinar cells and nerve cells, in which the mitochondria were distended with expansion of matrix space and the matrix substance was converted to granular or flocculent material. Lipid droplets of small size were also observed in the various cells. In the hepatocytes abnormal shaped microbodies were noted and the rough endoplasmic reticulum was dilated. Virus-like particles were not found. It is suggested that Reye syndrome is not a rare disease-entity in Korea since the cases of Reye syndrome comprised 3.2 percent of all pediatric autopsies during the same period. The significance and the specificity of the mitochondrial changes in Reye syndrome are discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome de Reye
/
Encéfalo
/
Microscopia Eletrônica
/
Rim
/
Fígado
/
Miocárdio
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
1978
Tipo de documento:
Artigo
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