The effects of UVA and UVB on proliferation and melanization in SK 23 melanoma cell lines / 대한피부과학회지
Korean Journal of Dermatology
;
: 732-737, 1993.
Artigo
em Coreano
| WPRIM
| ID: wpr-83506
ABSTRACT
BACKGROUND:
The visible cutaneous pigmentary response to ultraviolet A(UVA) is immediate, whereas ultraviolet B(UVB)-induced pigmentation appears after a delay of several days. However, some investigators reported that UVA also can induce delayed taniing.OBJECTIVE:
In order to determine whether the pigmentation induceil by UVA irradiation is accompanied by melanocytes responses which are the same or different from those following a UVB-indueed tan, we irraiated malignant melanoma cells to UVA or UVB.METHOD:
On the 7th day after irradiation of UVA or UVB, we exa nined the cell counts and the melanin content of control and experimental groups.RESULTS:
Although a dose of 10 J/cm decreased the number of manignant melanoma cells, there was no significant difference between the control and UVA-exposure griiups. But there was a significant decrease after UVB-exposun. UVB-exposure groups showed a significant increase of melanin cortent. A dose of 10 J/cm of UVA also induced a significant increase of melanin content.CONCLUSIONS:
The data suggest that UVA at a clinically relevant dose has a significant effect on human melanocytes. So, UVA very likely plays a role in the increased, melanization associated with delayed tanning.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pesquisadores
/
Curtume
/
Triacetonamina-N-Oxil
/
Pigmentação
/
Contagem de Células
/
Linhagem Celular
/
Melaninas
/
Melanócitos
/
Melanoma
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
1993
Tipo de documento:
Artigo
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