Immunohistochemical study on granulomatous skin deseases / 대한피부과학회지
Korean Journal of Dermatology
;
: 702-712, 1993.
Artigo
em Coreano
| WPRIM
| ID: wpr-83509
ABSTRACT
BACKGROUND:
A definition of granuloma is a focal chronic inflammatory response to tissue injury evolved by a poorly soluble substwice characterized by the accumulation and proliferation of the mono-nuclear histiocytic cells. The accuracy with which rnononuclear cells may be identified in skir. is much improved by the use of both heteroantisera and monoclonal antibodies directed against selected cellular antigens,OBJECTIVE:
Our purpose was to examine the staining patterns of anti-lysozyme, anti-a-1-antitrypsin, anti-S-100 protein antibodies, and MAC-387 monoclonal anibody in granulomatous skin diseases.METHOD:
We performed imminoperoxidase staining(the labelled str prvidin-biotin peroxidase complex method on the formalin-fixed, paraffin-embedded tissue specimens of granulomatous skin diseases.RESULTS:
S-100 protein positive dendritic cells were demonstrated in the granulomatous infiltrates as scattered pattern and MAC-387 positive cells were predominantly found in the center of granulomas, The staining pattern and percentage of positively stained cells of a--antitrypsin were similar to those of lysozyme. A1Pha-1-antitrypsin and lysozyme positive cells w re present in the center as well as lymphohistiocytic infiltrates of granulomas.CONCLUSION:
These data sugget that histiocytes are composed of heter igeneous groups of cells such as the mononuclear-phagocyte system and dendritic cell system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Dermatopatias
/
Células Dendríticas
/
Muramidase
/
Proteínas S100
/
Peroxidase
/
Granuloma
/
Histiócitos
/
Anticorpos
/
Anticorpos Monoclonais
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
1993
Tipo de documento:
Artigo
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