A clinical study of 225 parients with gebneralized vitiligo / 대한피부과학회지

ABSTRACT

BACKGROUND: Vitiligo is a relatively common acquired depigmentating disorder that affects at least 1 % of the population. The mode of transmission has not been clearly,stablished, but either polygenic or autosomal dominant with incomplete penetrance and variable expresion has been proposed. OBJECTIVE: Our purpose was to evaluate the causative factor, variable clinical features and current teratment of generalized vitiligo patients. METHOD: This clinical in vestigation was made with 225 outpatiens of generalized type vitiligo who had visited the Department of Dermatology, Keirnyung Universitv Hospital from January 1987 till December 1991. Results & CONCLUSION: 1. There were 125 female, (55.5%) and 100 males(44.4%). 2. The mean age of onset was 21.4 years(male . 24.3, female 19.1). 3. The mean age at the first visit was 27.5 years (male 28.8, female 26.5). 4. The mean duration of the disease was 10.7 years(male 9.9, female 10.9). 5. The mean interval between onset and visiting was 6.1 years (male 4.5, female 7.4). 6. The most common sites of involvernent at the first visit was tie face 11.7% (male 11.4%, female 11.8%). 7. The most common precipitating factor was trauma(8.8%). 8. The most common previous treatment was sunlight irradiaion after application of topical oxoralene(33.2%). 9. The most common degree of depigmented lesion was 5-10%(64.4%). 10. The most common occupations of the patients were students mals, and housewife females.