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The Effects of Sodium Nitroprusside on Platelet Aggregation Function during Intracranial Aneurysm Operation under Isoflurane Anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology ; : 217-223, 1996.
Artigo em Coreano | WPRIM | ID: wpr-83716
ABSTRACT

BACKGROUND:

The intravenous infusion of sodium nitroprusside is widely used as a means of producing deliberate hypotension in a variety of clinical situations. However, sodium nitroprusside reported to inhibit platelet aggregation. So we studied the effects of sodium nitroprusside on platelet function in patients undergoing intracranial aneurysm surgery with isoflurane anesthesia.

METHODS:

Platelet rich plasma from the patients receiving sodium nitroprusside was studied for aggregation in response to adenosine diphosphate, epinephrine and collagen. Maximum aggregation rate and maximum aggregation time were evaluated from the samples collected at pre-sodium nitroprusside infusion, 30min and 90min after sodium nitroprusside infusion, respectively. At the same time, bleeding time was measured.

RESULTS:

The mean maximum aggregation rate of adenosine diphosphate, epinephrine and collagen at pre-sodium nitroprusside infusion decreased significantly 30min and 90min after sodium nitroprusside infusion, respectively(P<0.05). But the maximum aggregation time showed no significant change. Prolongation of bleeding time was not observed after sodium nitroprusside infusion. Correlation between the total sodium nitroprusside dose delivered and the maximum aggregation rate of adenosine diphosphate, epinephrine and collagen were significant (r=0.797(P<0.05), r=0.732 (P<0.05) and r=0.737(P<0.05)).

CONCLUSIONS:

In situation where sodium nitroprusside is administered for deliberate hypotensive anesthesia during intracranial aneurysm operation, the platelet aggregation was inhibited by sodium nitroprusside. However, bleeding time was not prolonged.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sódio / Tempo de Sangramento / Plaquetas / Infusões Intravenosas / Nitroprussiato / Epinefrina / Difosfato de Adenosina / Aneurisma Intracraniano / Agregação Plaquetária / Colágeno Limite: Humanos Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 1996 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Sódio / Tempo de Sangramento / Plaquetas / Infusões Intravenosas / Nitroprussiato / Epinefrina / Difosfato de Adenosina / Aneurisma Intracraniano / Agregação Plaquetária / Colágeno Limite: Humanos Idioma: Coreano Revista: Korean Journal of Anesthesiology Ano de publicação: 1996 Tipo de documento: Artigo