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Human Caliciviruses in Korea: A New Prevalent Group Defined by RNA-Dependent RNA Polymerase Diversity
Journal of the Korean Society of Virology ; : 1-8, 1997.
Artigo em Coreano | WPRIM | ID: wpr-83740
ABSTRACT
Human caliciviruses (HuCVs) cause sporadic cases and outbreaks of acute gastroenteritis (AGE). Three maior genogrovps of HuCVs have been described including the Norwalk virus (NV)-, the Snow Mountain virus (SMA)-, and the Sapporo-genogroups. This study describes the detection and genetic variation of HuCVs from hospitalized infants with AGE in Korea by RT-PCR and sequencing. The cDNA fragments of 206 to 470bp corresponding to the region of 3 primer pairs (36/35, 35/51 or 3/51) in the polymerase region of NV were generated. Of 185 stools screened, 8% were positive by RT-PCR and their sequences showed that all strains contained the GLPSG and YGDD motifs which are conserved for HuCVs. Amino acid (aa) sequence analysis showed that these strains can be divided into 3 maior genogroups. High conservation was observed in that one strain shares 100% of as sequence with Southampton virus, another shares 99% with the Sapporo virus, and six strains share 90 to 95% with Snow Mountain virus. However, significant sequence variation was also found in other strains. This study indicates that all maior genogroups of HuCVs are circulating in Korea.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neve / Variação Genética / RNA Polimerase Dependente de RNA / Surtos de Doenças / Análise de Sequência / DNA Complementar / Vírus Norwalk / Sapovirus / Gastroenterite / Genótipo Limite: Humanos / Lactente País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of the Korean Society of Virology Ano de publicação: 1997 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neve / Variação Genética / RNA Polimerase Dependente de RNA / Surtos de Doenças / Análise de Sequência / DNA Complementar / Vírus Norwalk / Sapovirus / Gastroenterite / Genótipo Limite: Humanos / Lactente País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of the Korean Society of Virology Ano de publicação: 1997 Tipo de documento: Artigo