Investigation of primary liver carcinoma in patients with hepatitis B and its influencing factors / 公共卫生与预防医学

ABSTRACT

Objective To investigate the characteristics of primary liver carcinoma (PLC) in patients with hepatitis B and to analyze the influencing factors. Methods The clinical data of 308 patients with hepatitis B in our hospital from March 2016 to March 2019 were selected to investigate the occurrence of PLC. Univariate analysis and Logistic regression were used to analyze the influencing factors of PLC in patients with hepatitis B. Results The results of this survey showed that 116 of the 308 patients with hepatitis B had PLC (37.66%). The single factor analysis showed that age, diabetes mellitus, family history of PLC, smoking, drinking, eating habits, hepatitis B virus load, e antigen, antiviral therapy, fatty liver and cirrhosis were the influencing factors of PLC in patients with hepatitis B (P 50 years old, diabetes mellitus, family history of PLC, smoking, drinking, poor diet, positive HBV load, positive e antigen, ineffective antiviral therapy, fatty liver and cirrhosis were independent risk factors for PLC in patients with hepatitis B (P < 0.05). Conclusion Patients with hepatitis B were at high risk of PLC. They were affected by various factors. It is important to strengthen the preventative care of patients over 50 years old, with diabetes mellitus, family history of PLC, smoking, drinking, poor diet, hepatitis B virus load positive, e antigen positive, ineffective antiviral therapy, fatty liver, cirrhosis and so on.