Role of zinc finger proteins in the development and progression of hepatocellular carcinoma / 临床肝胆病杂志

ABSTRACT

There are complex mechanisms in the development and progression of hepatocellular carcinoma, which have not been fully clarified at present. Zinc finger protein family is the largest transcription factor family in human genome, and more and more evidence has shown that zinc finger proteins play an important role in the development and progression of hepatocellular carcinoma and are expected to become new tumor biomarkers and therapeutic targets for hepatocellular carcinoma. This article reviews the structure and biological functions of zinc finger proteins and their role and regulatory mechanisms in hepatocellular carcinoma.