Clinical rescue of 690 neonates with extremely low birth weight and very low birth weight in the latest 10 years: Experience from a single center / 第二军医大学学报

ABSTRACT

Objective: To explore the clinical rescue, clinical outcomes and complications in neonates with extremely low birth weight (ELBW, 0.05). In 2013-2017, there was a significant increase in the occurrence of neonatal respiratory distress syndrome (NRDS) (70.1% [314/448] vs 26.9% [65/242], P<0.01), bronchopulmonary dysplasia (BPD) (19.4% [87/448] vs 9.5% [23/242], P<0.01), necrotizing enterocolitis (NEC) (16.3% [73/448] vs 6.2% [15/242], P<0.01) and infection (50.4% [226/448] vs 29.8% [72/242], P<0.01), while asphyxia (36.6% [164/448] vs 41.7% [101/242], P<0.01), retinopathy of prematurity (ROP) (1.3% [6/448] vs 5.0% [12/242], P<0.01) and hypoglycemia (11.2% [50/448] vs 17.8% [43/242], P<0.05) were decreased as compared with those in 2008-2012. Conclusion: The overall survival rate is still low in neonates with ELBW and VLBW. Asphyxia and infection are still poorly controlled. The cooperation between institutions of obstetrics and neonatalogy is needed to improve the outcome of neonates with ELBW and VLBW.