Detection of pathogenic bacteria in bacterial liver abscess and the utilization of antibiotics / 第二军医大学学报

ABSTRACT

Objective To investigate the pathogenic bacterium distribution in bacterial liver abscess and sensitivity characteristics and utilization of antibiotics. Methods The clinical data of 125 patients with bacterial liver abscess, who were admitted to anting branch of our hospital from Oct. 2015 to Apr. 2017, were collected and analyzed retrospectively. The results of bacterial culture, drug resistance and use of antibiotics were investigated. Results Totally 94 patients were examined for pathogens, and 62 samples from 51 patients were positive to bacterial culture. A total of 62 strains of bacteria were detected, including 53 (85.48%) strains of Gram-negative bacteria, of which the most common bacteria were Klebsiella pneumoniae (33 strains) and Escherichia coli (10 strains), and 9 (14.52%) strains of Gram-positive bacteria, of which Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis were rather common (2 strains in each). Extended-spectrum β-lactamase (ESBL)-producing strains accounted for 6.06% (2/33) and 60.0% (6/10) in Klebsiella pneumonia and Escherichia coli, respectively. Ceftriaxone sodium, cefoperazone/sulbactam sodium, and imipenem/cilastatin sodium had higher defined daily dose system resulting in drug utilization index 1. Conclusion The most common pathogens causing bacterial liver abscess are Gram-negative bacteria, mainly Klebsiella pneumoniae and Escherichia coli. Clinically, we should strengthen the management of antibiotics use, identify the pathogens as soon as possible, and select optimum drugs based on drug-susceptibility test results to reduce drug resistance rate.